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The antibiotic regimen was then changed to nafcillin (2 g IV q4h) and gentamicin (3 mg/kg qday for 5 days) for MSSA positive endocarditis. The patient, however, did not improve and 2 weeks after admission, had a cardiac arrest and died. The key echocardiographic finding in right sided endocarditis is …

Another barrier to dalbavancin use is the lack of a defined optimal dosing and monitoring schedules. Several dosing strategies have been proposed that include once and twice weekly dosing with variable loading and maintenance dosages.67,68 Despite anecdotal success, more rigorous evaluation is clearly needed. Despite numerous anti-drug initiatives, the global …

Nonhuman primates, on the other hand, voluntarily consume different amounts of alcohol and allow us to conduct studies in an outbred species that shares significant physiological and genetic homology with humans while maintaining rigorous control over diet and other environmental cues. Moreover, immune systems of several nonhuman primate species are …